The Fourth Eleven battled difficult weather conditions away at the Horsfield against Colne.
Colne won the toss and elected to field, with Lowerhouse posting a competitive 179 for 8 from their 40 overs.
Shahbaz Mukhtar top scored with an unbeaten 49, while Hammad Aurangzeb added 36. Josh Brennand contributed 34 and Will Fallows made 26 as Lowerhouse put a useful total on the board despite the conditions.
In reply, Colne reached their target in the 37th over, finishing 180 for 5 from 36.3 overs.
Joshua Lord was the pick of the Lowerhouse bowlers, taking 3 for 40 from his 8 overs.